We all know that water and oil don’t mix. Therefore, it should come as no surprise that when we orally take CBD oil, it is not easily absorbed as our bodies consist of 65-70% water. What most people don’t realize is how poorly CBD oil is being absorbed. Tests have shown that at best 15-20%, but on average only 5-10% of the CBD oil we take orally is ultimately being absorbed. A staggering 80-95% of the CBD oil you consume, your body will never use.
The way that our body absorbs fatty compounds like CBD oil, is by encapsulating these compounds with a special molecule. This molecule has on one side a ‘fat-loving’ end (lipophilic) and on the other side it has a ‘water-loving’ end (hydrophilic). The molecules form a sphere around the CBD oil molecule and the lipophilic end attaches itself to the fatty compound and in doing so points the hydrophilic end towards the outside. This allows the sphere (with the CBD oil within) to become solubilized in water and pass the mucous membrane to enter the bloodstream. This process is called micellization.
To build these micelles the body needs time and energy. Whilst the body is working to encapsulate and absorb the CBD oil and other fatty components, the CBD is being destroyed by our stomach acid and by enzymes in our liver.
HOJI Powder mimics the creation of these spheres known as micelles, in a laboratory. This means that CBD products created are ready to be absorbed by the body almost instantly. The CBD Powder HOJI s can easily pass through the mucous membrane, which consists of 90-95% of water, enter the bloodstream and be delivered to the right location in your body. The result is increased absorption from an average of 5-10% to almost 100% – furthermore the effects are more potent and the onset faster.
These days the most common way to consume CBD is orally. A large number of CBD oil-based products have been, and are being launched every day and sold online, in specialty stores but also more and more frequently in high street retail shops. These CBD oils are dissolved in a carrier which is edible vegetable oil. Recently, questions are being asked about the efficacy of taking CBD this way because of the low absorption rate of the active ingredient.
Oral bioavailability of any substance such as CBD is a measure of the rate and extent to which it is reaching the systemic circulation. It is a key parameter which affects its efficacy and the likelihood of adverse effects. By definition, when a medication is administered intravenously, its bioavailability is 100%. Studies of oral bioavailability have received considerable attention as being one of the principal pharmacokinetic properties of drugs and significant progress has been made in understanding the various components of this complex puzzle, including solubility, partition coefficients, absorption, metabolism, and excretion.